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NameMr. Robert Logue
Organization or InstitutionSoutheastern University
TopicOrganic Chemistry
Title

Synthesis of Peptidomimetics as Potential Anticancer Agents and Biomedical Applications

Author(s)

Robert Logue, Zoie Wells, Aaron Todman, and Ralph Salvatore Ph. D.*

Author Institution(s)

Southeastern University

Abstract

Numerous physiological and pathological stimuli induced programmed cell death (apoptosis), and the Bcl-2 family of oncoproteins plays a central role in this regulation. Proteins such as Bcl-2 are known to inhibit apoptosis, and uncontrolled cell survival due to Bcl-2 overexpression has been proven to make a significant contribution to tumor formation. With this in mind, we have directed our attention toward the synthesis of a variety of non-peptide inhibitors of oncoproteins Bcl-2. Recently, we have disclosed efficient protocols leading to the synthesis of carbazate and dithiocarbazate peptidomimetics, respectively. This study is now being extended to the synthesis of other de novo analogs with similar structural features to natural proteins, that may interrupt protein-protein interactions. Utilizing our aforementioned protocols, various scaffoldings are being employed for the development of novel artificial biomolecules, which may result in interesting biological behaviors regarding the disruption of protein-protein interactions and furthermore, may serve as potential therapeutics in clinical chemotherapy. Additionally, numerous other synthetic pseudo-peptides containing a plethora of additional biomedical significance will be presented.