Potential New Synthetic Ketogenic Molecules: Ester Derivatives

Mohammad Nazmus Sakib, Edward Turos

University of South Florida

‘Ketone bodies’ are produced in our liver during prolong fasting and carbohydrate restricted diet, in a process called ketosis. Ketosis has already been proven as effective tool for medical uses as it showed influence on treating epilepsy, type 2 diabetes and weight loss. ‘Ketone bodies’ are produced by metabolism of molecules called Long chain triglycerides (LCTs) which we gain from dietary fat. However, medium and shorter chain triglycerides made from fatty acids are more ketogenic. Herein, we aimed at synthesis of short and medium chain ester derivatives of potential new ketogenic molecules for further exploration.